Sign up to disable those pesky ads. easyist boss hands down saddler hardest boss im tied with u3 and bitores mendez
not sure if i've posted here already but Easy: too many, guess i'll put ol' Jacky boy Hard: none of'em really...guess I'll say Chief Mendez
The easiest one for me was Krauser. Once you take your dagger out he's finished lol just keep shaking it and he won't even touch you The hardest one at the biginning was the left hand of Salazar. I had so hard times killing it! I realized that i could freeze it just randomly after the 3rd time i finished the game lol
I was really kinda shocked and dumbfounded when I beat Sadler without trying the first time around ... so he wasn't very difficult. Salazar wasn't so bad either. I think I would have to go with Mendez as well, especially on professional. By then I have the handgun and bolt action rifle tuned up as much as possible and the first shotgun not tuned up at all (I usually save that money to buy the Riot Gun when entering the castle and just stick to the handgun and rifle until then), so it generally takes a ton of ammunition and patience.
Recalling my first time playing it... Easy: Del Lago, Salazar, Bitorez and Dr. Salvador (and even he killed me about 3 times outside Bitorez's house) Hard: Everything else... LOL The thing is, I played RE4 before any othe RE title, not knowing anything but the vague idea the movies give... I had just bougth a PS3 and never played anything but Mario&friends, so the transition between a game were you just stomp enemies into one where you have to blast their head off was made rather harshly... I must say I've never enjoyed a game the same way I did with RE4... I also must say that it took 25 and a half hours to finish it the 1st time... I must say too, I didn't found out until the 2nd round that you could upgrade your weapons beyond just changing them for other models...